CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation
Abstract Background Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex differences.CTCF, a master chromatin conformation regulator, is enriched at escape vogue regions and may play an important